منابع مشابه
The pancreas cancer microenvironment.
Pancreatic ductal adenocarcinoma (PDA) is a common and lethal malignancy resulting in more than 250,000 deaths per year worldwide. Despite extensive efforts, cytotoxic and targeted therapies have provided only limited efficacy for patients with PDA to date. One contributing factor to the failure of systemic therapies may be the abundant tumor stromal content that is the characteristic of PDA. T...
متن کاملCancer of the pancreas.
The malignant growth may originate either in the duct cells or acini of the gland, or in the islets of Langerhans. Cancer of the islet cells is uncommon and is discussed in a later section. About 80% of tumours are adenocarcinomas which arise from ductular epithelium. The neoplasm is hard and scirrhous and the cells are columnar or cuboidal with clear-cut cellular outlines. Cancers arising from...
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Introduction: The G-protein coupled receptor 30 (GPR30) gene is a member of the G-protein coupled receptor (GPCR) family; involved in breast, endometrial, and ovarian cancers. Many GPCR receptors that are implicated in several types of human cancers are correlated with increased cell proliferation and tumor progression; especially GPR30 gene. Methods: The breast cancer MCF-7 and MDA-MB-231 cel...
متن کاملThe Tumor Microenvironment and Cancer
Tumors are now recognized as structures of multiple cell types. It is increasingly appreciated that as the cancer progresses, the surrounding microenvironment is activated in support, coevolving through continuous paracrine communication and supporting carcinogenesis. Therefore, the characterization of these interactions, and the molecular identification of key mediators, will provide insights ...
متن کاملStaging cancer of the pancreas
Pancreatic carcinoma is the fourth cause of death from cancer in the United States, with a survival rate at 5 years of less than 5%. About 60% of tumors originate at the head of the pancreas, 15% in the body, 5% in the tail; 20% are diffuse within the pancreas. This article discusses the imaging and staging of pancreatic cancer.
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2012
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-11-3114